Masters of Immunology
Roni Nowarski, Nicola Gagliani, Samuel Huber and Richard A. Flavell
Cancer Immunol Res August 1 2013 1 (2) 77-84; DOI:10.1158/2326-6066.CIR-13-0081
Findings from preclinical studies and case studies of patients indicate potential synergy between radiation therapy and ipilimumab immunotherapy. Barker and colleagues performed a retrospective study on the outcome of melanoma patients treated with this therapeutic combination and found no significant increase in adverse events or compromise in efficacy, suggesting that prospective evaluation of this regimen is warranted.
Using somatic cell nuclear transfer, which generates mice bearing T cells with the rearranged TCR genes expressed from endogenous loci under physiologic control, Dougan and colleagues have generated mouse models to investigate the role of TCR affinity in the immune response to melanoma.
Doucette and colleagues analyzed The Cancer Genome Atlas glioblastoma database and found differential expression of distinct glioma antigens and immunosuppressive and effector genes among the glioblastoma subtypes, which may influence responses to immune therapeutic strategies in patients.
Mobilizing the latent pool of tumor-specific T cells in patients is a goal for immunotherapy. Using Salmonella typhimurium to deliver tumor-specific antigens into the tumor, Binder and colleagues found that when combined with αPD-L1 blocking antibodies, this regimen rescued endogenous dysfunctional tumor-specific CD8 T cells and eradicated the established tumors.
Poli and colleagues used immuno-PET imaging after dosimetric administration of 124I-L19SIP to predict the doses to be delivered by subsequent radretumab (131I-L19SIP) radioimmunotherapy in patients with brain metastases from solid tumors. They describe the method they developed for accurate determination of the expected 131I-L19SIP radioimmunotherapy doses to the bone red marrow, lesions, and healthy organs and identify an unexpected variability of antibody uptake in different lesions within the same patient.