Checkpoint blockade is becoming more widespread, so the timely and accurate diagnosis of immune-related colitis is increasingly important. By comparing diagnoses with colonoscopy data, CT scans were a fast, accurate, and non invasive mode of diagnosing ipilimumab-induced immune-related colitis.
Triple-negative breast cancers (TNBCs) are often infiltrated by T cells. These tumors counteracted T-cell activity through hypomethylated IDO1 promoters and increased IDO1 expression in response to IFNγ, providing a rationale for treatment of TNBC with IDO inhibitors.
Lung cancer cells exposed to granulocyte serine proteases increased the presentation of both endogenous peptides and the exogenous, protease-derived, HLA-A2-restricted PR1 peptide. Circulating CTLs specific for these peptides were identified in lung cancer patients.